RESEARCH OVERVIEW
Professor Holyoak’s laboratory research interests lie in the areas of enzyme structure, mechanism, inhibition, and allostery. At the most general level, our research focuses on the role that conformational plasticity plays in these areas of enzymology and how these dynamic aspects of enzyme structure can be exploited in the catalytic function and regulation of various biomedically relevant enzymes.
Research Approaches
Enzyme structure and function
Biochemistry and biophysics
Molecular interactions of enzymes
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COLLABORATIONS AND PARTNERSHIPS
Achievements
3
Patents filed and preliminary patents
>50
Different proteins successfully purified
>30
Crystal structures published
Academic Collaborators
Canadian Light Source
Cornell High-Energy Synchrotron Source
Diamond Light Source
Cornell University
University of Colorado Denver, Anschutz Medical Campus
Dalhousie University
University of Oxford
University of Waterloo, Departments of Chemistry and Pharmacy
Industrial Partners
IGAN Biosciences
TEAM MEMBERS
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Holyoak Lab 